How to Use Triptorelin
Complete guide to Triptorelin dosing, administration, timing, and protocol recommendations.
Quick Overview
Triptorelin is a synthetic analog of gonadotropin-releasing hormone (GnRH) with a D-tryptophan swapped in at position 6, which makes it far more potent and longer-lasting than the natural hormone. As a long-acting depot it is FDA-approved to shut down testosterone in advanced prostate cancer (Trelstar) and to pause early puberty in children (Triptodur), and in Europe it is sold as Decapeptyl, including a short-acting 0.1 mg form used in IVF. In men's health circles it is known for something else: a single small dose used to 'restart' testosterone after steroid use. That idea rests on very little published evidence.
Dosing Guidelines
Common Dose
Depot per label (3.75-22.5 mg); 100 mcg single dose for restart (community-reported)
Frequency
Single dose for the stimulation test; every 4, 12 or 24 weeks for depots
Dose Range
100 mcg single dose (stimulation test) to 22.5 mg depot every 24 weeks
Note: The restart use relies on the short-acting acetate form at 100 mcg once, mirroring the diagnostic stimulation test. Depot products (Trelstar, Triptodur, Decapeptyl depots) suppress testosterone for months and are the wrong tool for recovery. Blood work before and after is the only way to know whether it did anything.
Administration Method
Intramuscular injection (depots); subcutaneous or intramuscular for the 100 mcg short-acting dose
Best Time to Take
Morning for the single 100 mcg dose; depots on the scheduled date
The stimulation test is usually done in the morning so LH can be measured 45-60 minutes later. Depot timing only needs to follow the 4, 12 or 24 week schedule.
Protocol Duration
Ongoing for approved depot uses; single injection for the stimulation test
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Hot flushes (very common with depot use)
- •Erectile dysfunction, low libido and testicular atrophy with ongoing suppression
- •Temporary testosterone flare in the first days (can worsen prostate cancer symptoms)
- •Prolonged testosterone suppression if a depot form is used by mistake
- •Headache and skeletal pain
Frequently Asked Questions
What is the recommended dose for Triptorelin?
Depot per label (3.75-22.5 mg); 100 mcg single dose for restart (community-reported)
How do you administer Triptorelin?
Intramuscular injection (depots); subcutaneous or intramuscular for the 100 mcg short-acting dose
When is the best time to take Triptorelin?
Morning for the single 100 mcg dose; depots on the scheduled date
How long should you use Triptorelin?
Ongoing for approved depot uses; single injection for the stimulation test
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.