THR-123 Alternatives
Explore peptides similar to THR-123. Compare mechanisms, effects, and find the best alternative for your research.
THR-123
Metabolic
An orally administered cyclized small peptide that mimics bone morphogenetic protein 7 (BMP-7) signaling through the ALK3 receptor. Originally developed for kidney fibrosis where it reversed established fibrosis in animal models. A 2025 Nature Communications study from the Diabetes Research Institute showed THR-123 regenerated insulin-producing pancreatic beta cells and reversed diabetes in preclinical models. No human clinical trials yet.
Similar Peptides
SLU-PP-332
Metabolic
A synthetic small molecule developed at Saint Louis University that activates estrogen-related receptors (ERRs), mimicking the metabolic effects of aerobic exercise. Technically not a peptide but a small organic molecule (MW 290.32), widely discussed in the peptide community as an "exercise mimetic" that boosts fat oxidation, endurance, and mitochondrial function without stimulant effects.
Pancragen
Metabolic
A synthetic tetrapeptide (Lys-Glu-Asp-Trp) bioregulator originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression. Studied for age-related metabolic disturbances including type 2 diabetes.
TB-500
Healing
A synthetic 17-amino acid fragment of Thymosin Beta-4 (TB-4). Unlike TB-4, TB-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. Note: Many vendors mislabel TB-4 as 'TB-500' in premixed products.
Retatrutide
Weight Loss
A triple agonist targeting GLP-1, GIP, and glucagon receptors. Phase 3 trials show up to 28.7% weight loss (71 lbs average), the highest of any obesity drug. Expected FDA approval late 2026 to early 2027.
KLOW Blend
Peptide Blend
An advanced multi-peptide blend combining BPC-157 (10mg), TB-500 (10mg), GHK-Cu (50mg), and KPV (10mg) totaling 80mg per vial. Evolution of the Glow stack with added KPV for enhanced anti-inflammatory and gut health benefits.
GHRP-6
Growth Hormone
One of the first synthetic GH secretagogues developed. Strongly stimulates GH release and significantly increases appetite through ghrelin receptor activation.
All Metabolic Peptides
Pancragen
A synthetic tetrapeptide (Lys-Glu-Asp-Trp) bioregulator originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression. Studied for age-related metabolic disturbances including type 2 diabetes.
SLU-PP-332
A synthetic small molecule developed at Saint Louis University that activates estrogen-related receptors (ERRs), mimicking the metabolic effects of aerobic exercise. Technically not a peptide but a small organic molecule (MW 290.32), widely discussed in the peptide community as an "exercise mimetic" that boosts fat oxidation, endurance, and mitochondrial function without stimulant effects.