A synthetic tetrapeptide (Lys-Glu-Asp-Trp) bioregulator originally isolated from bovine pancreatic cells. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it directly interacts with DNA to regulate pancreatic gene expression. Studied for age-related metabolic disturbances including type 2 diabetes.

Is Pancragen FDA approved?

No, Pancragen is not FDA approved. Current status: Approved in Russia - Clinical use for pancreatic support

What are the side effects of Pancragen?

Reported side effects of Pancragen include: Generally well-tolerated, No significant adverse effects reported in studies, Individual intolerance possible, Should not replace diabetes medications.

What is the typical dosing for Pancragen?

Khavinson bioregulator dosing - clinically used in Russia. Common doses observed in research: 10-20 mg daily (1-2 capsules), Standard: 10 mg per capsule. Duration: 30-day courses with 3-6 month breaks. Administration: Oral capsules, before meals.

Metabolic

Pancragen

Also known as: KEDW Tetrapeptide, Lys-Glu-Asp-Trp, Pancreas Bioregulator

Clinical Trials

Popular For

Pancreatic health, blood sugar, metabolic support

Key Facts: Pancragen

Category: Metabolic
FDA Status: Not FDA Approved
Clinical Status: Approved in Russia - Clinical use for pancreatic support
Administration: Oral capsules, before meals
Typical Dose: 1-2 capsules (10-20 mg) daily
Frequency: 1-2x daily, before meals
Evidence Level: Human Trials
Duration: 30-day courses with 3-6 month breaks

Also Known As

KEDW Tetrapeptide, Lys-Glu-Asp-Trp, Pancreas Bioregulator

Mechanism of Action

Pancragen works through epigenetic regulation by interacting with chromatin complexes and DNA structures. Research shows it upregulates critical transcription factors for pancreatic cell maturation including Pdx1, Pax6, Ptf1a, Foxa2, Nkx2.2, and Pax4. Its small size (~576 Da) allows it to traverse cellular membranes and interact with nuclear components including histones and DNA. May also modulate inflammatory responses and support antioxidant defenses.

Research Summary

Research in old rhesus monkeys demonstrated Pancragen corrected impaired glucose tolerance, normalized insulin and C-peptide levels, and improved endocrine pancreatic function. Studies published in Bulletin of Experimental Biology and Medicine (2013, 2015) show effects on pancreatic cell differentiation during aging. Used clinically in Russia for chronic pancreatitis and type 2 diabetes support.

Clinical Status:Approved in Russia - Clinical use for pancreatic support

Trial Progress:Preclinical

Pre

III

FDA

Dosing Information

Human Trials·Clinical use in Russia, primate studies, human applications

Typical DosingⓘDoses commonly used by people in practice, based on community reports and anecdotal experience.

Community experience

Common Dose

1-2 capsules (10-20 mg) daily

Range

10-20 mg per day

Frequency

1-2x daily, before meals

Khavinson bioregulator for pancreatic and metabolic support. Studies in aged rhesus monkeys showed improvement in glucose tolerance. Used in Russia for chronic pancreatitis and as adjunct for type 2 diabetes. Should not replace standard diabetes treatment.

Research DosingⓘDoses from published scientific studies and clinical trials. May include human or animal research.

Scientific studies

Khavinson bioregulator dosing - clinically used in Russia

Doses from Studies

10-20 mg daily oral

Russian Clinical Practice - Chronic pancreatitis and T2D support protocols ↗

10 mg daily (primate studies)

Bull Exp Biol Med 2013 - Pancragen effects on pancreatic differentiation during aging ↗

Duration

30-day courses with 3-6 month breaks

Administration

Oral capsules, before meals

Timing & Administration

Best Time to Take

Morning, before breakfast

1-2 times daily

Food Recommendation

With or without food

Why This Timing?

Pancreatic support peptide taken fasted for optimal absorption. Timing with meals may support glucose metabolism.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

●Generally well-tolerated
●No significant adverse effects reported in studies
●Individual intolerance possible
●Should not replace diabetes medications

References

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Educational Information Only

This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.

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