How to Use Retatrutide
Complete guide to Retatrutide dosing, administration, timing, and protocol recommendations.
Quick Overview
Retatrutide is the heavy hitter of the new weight-loss drugs: a once-weekly injectable peptide that hits three receptors at once - GIP, GLP-1, and glucagon - earning it the nickname triple-G agonist. In a phase 2 trial it produced some of the largest weight loss ever recorded for a drug, up to roughly 24 percent of body weight at the top dose. It is investigational, made by Eli Lilly, and not yet FDA approved as of 2026.
Dosing Guidelines
Common Dose
4-12 mg weekly
Frequency
Once weekly, same day each week
Dose Range
1-12 mg weekly (titrate up slowly)
Note: Triple agonist (GLP-1/GIP/glucagon). Start low (1-2 mg) and titrate up to minimize GI side effects. Not yet FDA approved but available through compounding.
Administration Method
Subcutaneous injection weekly
Best Time to Take
Morning, same day each week
As a triple agonist, consistent weekly timing is important. Morning allows for side effect monitoring.
Protocol Duration
Long-term use expected
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Nausea (dose-related)
- •Diarrhea
- •Vomiting
- •Constipation
- •Heart rate increases
Frequently Asked Questions
What is the recommended dose for Retatrutide?
4-12 mg weekly
How do you administer Retatrutide?
Subcutaneous injection weekly
When is the best time to take Retatrutide?
Morning, same day each week
How long should you use Retatrutide?
Long-term use expected
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.