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Weight Loss

Retatrutide

Also known as: LY3437943, Triple G

Clinical Trials
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Popular For

Weight loss, metabolic syndrome, liver fat reduction

Key Facts: Retatrutide

Category
Weight Loss
FDA Status
Not FDA Approved
Clinical Status
Phase 3 Clinical Trials - NDA expected 2026, approval expected late 2026/early 2027
Administration
Subcutaneous injection weekly
Typical Dose
4-12 mg weekly
Frequency
Once weekly, same day each week
Evidence Level
Human Trials
Duration
Long-term use expected
Also Known As
LY3437943, Triple G

Mechanism of Action

Retatrutide activates three receptors: GLP-1 for appetite suppression and glucose control, GIP for enhanced insulin response and metabolic effects, and glucagon for increased energy expenditure and fat oxidation. The triple mechanism provides synergistic effects.

Research Summary

Phase 3 TRIUMPH-4 trial (Dec 2025) showed 28.7% weight loss at 68 weeks, with average loss of 71 lbs. Also showed significant osteoarthritis pain relief, reduced cardiovascular risk markers, and 14 mmHg blood pressure reduction. Seven more Phase 3 readouts expected in 2026. NDA submission expected late 2025/early 2026.

Clinical Status:Phase 3 Clinical Trials - NDA expected 2026, approval expected late 2026/early 2027
Trial Progress:Phase III
Pre
I
II
III
IV
FDA

Dosing Information

Human Trials·Human studies conducted, not FDA approved

Typical Dosingⓘ

Community experience

Common Dose

4-12 mg weekly

Range

1-12 mg weekly (titrate up slowly)

Frequency

Once weekly, same day each week

Triple agonist (GLP-1/GIP/glucagon). Start low (1-2 mg) and titrate up to minimize GI side effects. Not yet FDA approved but available through compounding.

Research Dosingⓘ

Scientific studies

Doses from clinical trials

Duration

Long-term use expected

Administration

Subcutaneous injection weekly

Timing & Administration

Best Time to Take

Morning, same day each week

Once weekly, same day and time

Food Recommendation

With or without food

Why This Timing?

As a triple agonist, consistent weekly timing is important. Morning allows for side effect monitoring.

Possible Side Effects

Not everyone experiences these effects. Individual responses vary based on dosage, duration, and personal factors.

  • ●Nausea (dose-related)
  • ●Diarrhea
  • ●Vomiting
  • ●Constipation
  • ●Heart rate increases
  • ●Hypersensitivity reactions
  • ●Dysesthesia - skin sensitivity/tingling (~21% at highest dose, TRIUMPH-4 data)
  • ●Pancreatitis (rare)
  • ●Currently in Phase 3 trials

References

Related Peptides

Peptides commonly compared with Retatrutide or used in similar applications.

Semaglutide

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A GLP-1 receptor agonist with multiple FDA approvals including weight loss, T2D, CV risk reduction, and kidney protection. Wegovy pill approved Dec 2025 as first oral GLP-1 for weight loss.

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Tirzepatide

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A dual GIP/GLP-1 receptor agonist representing the next generation of incretin-based therapies. Shows superior weight loss compared to semaglutide in head-to-head trials. First medication approved for obstructive sleep apnea.

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Survodutide

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A dual GLP-1/glucagon receptor agonist in development for obesity and MASH. Has FDA Breakthrough Therapy Designation for MASH with fibrosis.

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Cagrilintide

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A long-acting amylin analog developed by Novo Nordisk for obesity treatment. Works through a different mechanism than GLP-1 agonists, targeting amylin receptors in the brain to reduce appetite and slow gastric emptying. Shows enhanced weight loss when combined with semaglutide (CagriSema).

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Orforglipron

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An oral non-peptide GLP-1 receptor agonist. NDA under FDA review with decision expected April 10, 2026. If approved, will compete directly with oral Wegovy.

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CagriSema

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A combination of semaglutide and cagrilintide (amylin analog). The most effective weight loss drug candidate, showing 22.7% body weight reduction in Phase 3 trials - superior to any single-agent GLP-1.

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