Retatrutide Alternatives

Explore peptides similar to Retatrutide. Compare mechanisms, effects, and find the best alternative for your research.

Original

Retatrutide

Weight Loss

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A triple agonist targeting GLP-1, GIP, and glucagon receptors. Represents the next evolution beyond dual agonists like tirzepatide, showing unprecedented weight loss in trials.

Similar Peptides

Semaglutide

Weight Loss

FDA

A GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management. One of the most effective pharmaceutical weight loss interventions available.

Tirzepatide

Weight Loss

FDA

A dual GIP/GLP-1 receptor agonist representing the next generation of incretin-based therapies. Shows superior weight loss compared to semaglutide in head-to-head trials.

Orforglipron

Weight Loss

An oral non-peptide GLP-1 receptor agonist. Could provide injection-free alternative to semaglutide and tirzepatide.

CagriSema

Weight Loss

A combination of semaglutide and cagrilintide (amylin analog) in development. Aims to provide superior weight loss through dual mechanisms.

Survodutide

Weight Loss

A dual GLP-1/glucagon receptor agonist in development for obesity and NASH. Combines appetite suppression with increased energy expenditure.

Cagrilintide

Weight Loss

A long-acting amylin analog developed by Novo Nordisk for obesity treatment. Works through a different mechanism than GLP-1 agonists, targeting amylin receptors in the brain to reduce appetite and slow gastric emptying. Shows enhanced weight loss when combined with semaglutide (CagriSema).

All Weight Loss Peptides

Semaglutide

FDA Approved

A GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management. One of the most effective pharmaceutical weight loss interventions available.

Tirzepatide

FDA Approved

A dual GIP/GLP-1 receptor agonist representing the next generation of incretin-based therapies. Shows superior weight loss compared to semaglutide in head-to-head trials.

AOD-9604

A modified fragment of human growth hormone (amino acids 177-191) studied for fat metabolism effects without the broader hormonal effects of full GH.

HGH Fragment 176-191

The lipolytic fragment of human growth hormone. Contains the fat-burning portion of HGH without effects on blood sugar or cell proliferation.

Liraglutide

FDA Approved

An FDA-approved GLP-1 receptor agonist for type 2 diabetes and chronic weight management. The predecessor to semaglutide with daily dosing.

Dulaglutide

FDA Approved

An FDA-approved weekly GLP-1 receptor agonist for type 2 diabetes. Fused to an Fc antibody fragment for extended duration of action.

Exenatide

FDA Approved

The first GLP-1 receptor agonist approved for diabetes. Derived from Gila monster saliva. Available in twice-daily and weekly formulations.

Survodutide

A dual GLP-1/glucagon receptor agonist in development for obesity and NASH. Combines appetite suppression with increased energy expenditure.

Quick Comparison

PeptideCategoryFDA StatusAction
RetatrutideWeight LossNot ApprovedOriginal
SemaglutideWeight Loss✓ ApprovedCompare →
TirzepatideWeight Loss✓ ApprovedCompare →
OrforglipronWeight LossNot ApprovedCompare →
CagriSemaWeight LossNot ApprovedCompare →