MK-677 vs Ipamorelin
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Ibutamoren, Nutrobal
An orally active growth hormone secretagogue that mimics ghrelin. Not a peptide technically, but frequently discussed alongside GH peptides due to similar effects.
Also: IPAM, NNC 26-0161
A selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin. Considered one of the safest GHRPs.
Key Comparison Insights
- Both peptides belong to the Growth Hormone category, suggesting similar primary applications.
Detailed Comparison
| Attribute | MK-677 | Ipamorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| FDA Status | Not FDA Approved | Not FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | MK-677 binds to ghrelin receptors (GHSR) in the brain, stimulating sustained GH release and increasing IGF-1 levels. Unlike injectable GHRPs, it's orally bioavailable and has a long half-life providing 24-hour GH elevation. | Ipamorelin binds to ghrelin receptors (GHSR) in the pituitary gland, triggering growth hormone release. Unlike other GHRPs, it does not stimulate significant ACTH, cortisol, prolactin, or aldosterone release, making it highly selective for GH. |
| Common Dosing | 10-25 mg daily Once daily, often before bed | 200-300 mcg 2-3x daily 2-3x daily |
| Administration | Oral | Subcutaneous injection |
| Typical Duration | 8-12 weeks or longer | 8-12 weeks typical |
| Best Time to Take | Before bed | Before bed or morning (fasted) |
Possible Side Effects May vary by individual |
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| Research Summary | Studies show significant increases in GH and IGF-1 levels, improved sleep quality, and increased lean body mass. Research in elderly shows reversal of diet-induced nitrogen wasting. Long-term studies demonstrate sustained efficacy. | Clinical studies show dose-dependent GH release with minimal side effects. Research demonstrates improved bone density in postmenopausal women and potential benefits for muscle mass and recovery. Has been studied for post-surgical recovery. |
Frequently Asked Questions: MK-677 vs Ipamorelin
What is the difference between MK-677 and Ipamorelin?
MK-677 is a growth hormone peptide that an orally active growth hormone secretagogue that mimics ghrelin. not a peptide technically, but frequently discussed alongside gh peptides due to similar effects. Ipamorelin is a growth hormone peptide that a selective growth hormone secretagogue that stimulates gh release without significantly affecting cortisol or prolactin. considered one of the safest ghrps. The main differences lie in their mechanisms of action and clinical applications.
Which is better, MK-677 or Ipamorelin?
Neither is universally "better" - the choice depends on your specific goals. MK-677 is typically used for growth hormone purposes, while Ipamorelin is used for growth hormone. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can MK-677 and Ipamorelin be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using MK-677 and Ipamorelin together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of MK-677 and Ipamorelin is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.