THR-123 Dosage Calculator

Calculate reconstitution volumes, injection doses, and doses per vial for THR-123.

THR-123 Dosing Quick Reference

THR-123 typical dose: 2-5 mg orally per day (community starter, extrapolated from animal data), administered Once daily.

Common Dose

2-5 mg orally per day (community starter, extrapolated from animal data)

Frequency

Once daily

Administration

Oral (cyclized peptide is GI-stable, which is unusual for a peptide). Some animal studies use intraperitoneal injection.

Duration

2-8 weeks in animal model studies; community protocols mirror this with 4-8 week cycles

Reconstitution Calculator

Enter your vial and water amounts

Vial Size (mg)

Bacteriostatic Water (mL)

Body Weight (optional, for weight-based calculations)

Syringe Type

Results

Concentration

2,500 mcg/mL

Injection Volume (2 mcg)

0.001 mL

Syringe Units

0.1 units

Doses Per Vial

2500 doses

Dosing Notes

There are no human clinical trials for THR-123. Community-reported ranges so far are extrapolated from the mouse data (0.5-2 mg/kg orally daily, Nature Medicine 2012 + Nature Communications 2025) using standard FDA allometric scaling (mouse to human: divide mg/kg by 12.3). For a 70 kg adult that lands at roughly 2-10 mg orally per day. The handful of community protocols circulating start at the low end (2-5 mg/day) and titrate based on tolerance. THR-123 is unusual in that it is genuinely orally bioavailable thanks to its cyclized structure, so injection is not necessary. Cycles typically run 4-8 weeks, matching the animal model durations.

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