How to Use SYN-AKE
Complete guide to SYN-AKE dosing, administration, timing, and protocol recommendations.
Quick Overview
SYN-AKE is DSM's trade name for dipeptide diaminobutyroyl benzylamide diacetate, the 'snake venom' peptide in a lot of anti-wrinkle creams. The marketing says it mimics Waglerin-1, a toxin from the temple viper. To be clear: there is no venom in it. It is a tiny synthetic molecule, and the evidence that it relaxes wrinkles comes almost entirely from the manufacturer.
Dosing Guidelines
Common Dose
1-4% of the SYN-AKE solution in a finished product
Frequency
Once or twice daily
Dose Range
1-4% (manufacturer suggested range)
Note: These are cosmetic formulation levels, not personal doses. There is no injectable or oral use with human data, and the venom-mimic framing does not mean it acts like an injectable neurotoxin.
Administration Method
Topical (serums, creams)
Best Time to Take
Morning and/or evening, on clean skin
Timing has no known effect on a topical peptide; the manufacturer study used twice-daily application.
Protocol Duration
28 days in the manufacturer study; ongoing use to maintain any effect
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Generally well tolerated in cosmetic use
- •Mild tingling, redness or irritation (uncommon)
- •Contact allergy possible, as with any skincare ingredient
- •Does not paralyze muscles the way botulinum toxin injections do
Frequently Asked Questions
What is the recommended dose for SYN-AKE?
1-4% of the SYN-AKE solution in a finished product
How do you administer SYN-AKE?
Topical (serums, creams)
When is the best time to take SYN-AKE?
Morning and/or evening, on clean skin
How long should you use SYN-AKE?
28 days in the manufacturer study; ongoing use to maintain any effect
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.