How to Use Semaglutide
Complete guide to Semaglutide dosing, administration, timing, and protocol recommendations.
Quick Overview
A GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management. One of the most effective pharmaceutical weight loss interventions available.
Dosing Guidelines
Common Dose
1-2.4 mg weekly (after titration)
Frequency
Once weekly
Dose Range
0.25-2.4 mg weekly
Note: Titrate up slowly over 16-20 weeks to minimize GI side effects. Start at 0.25 mg, increase every 4 weeks. Many stay at 1 mg if tolerating well.
Administration Method
Subcutaneous injection weekly, or oral (Rybelsus)
Best Time to Take
Morning, same day each week
Weekly injection should be at a consistent time. Morning allows monitoring for any side effects during waking hours.
Protocol Duration
Long-term / chronic use
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Nausea (common, usually transient)
- •Vomiting
- •Diarrhea
- •Constipation
- •Abdominal pain
Frequently Asked Questions
What is the recommended dose for Semaglutide?
1-2.4 mg weekly (after titration)
How do you administer Semaglutide?
Subcutaneous injection weekly, or oral (Rybelsus)
When is the best time to take Semaglutide?
Morning, same day each week
How long should you use Semaglutide?
Long-term / chronic use
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.