How to Use Pentapeptide-18
Complete guide to Pentapeptide-18 dosing, administration, timing, and protocol recommendations.
Quick Overview
Pentapeptide-18 is Lipotec's Leuphasyl, a 'Botox-like' cosmetic peptide modeled on enkephalins, the body's own calming neuropeptides. It is mostly sold alongside Argireline, with the claim that the two relax expression lines better together. It is a cosmetic ingredient, and the evidence is small and mostly manufacturer-run.
Dosing Guidelines
Common Dose
About 2-5% of the commercial solution in a finished product
Frequency
Once or twice daily
Dose Range
0.5-5% in published and manufacturer studies (percent of the ingredient, not pure peptide)
Note: These are cosmetic formulation levels, not personal doses. It is usually combined with Argireline. There is no injectable or oral use with human data, and it does not work like a botulinum toxin injection.
Administration Method
Topical (serums, creams)
Best Time to Take
Morning and/or evening, on clean skin
Timing has no known effect on a topical peptide; consistent daily use is what the studies tested.
Protocol Duration
28 days to 2 months in studies; ongoing use to maintain any effect
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Generally well tolerated in cosmetic use
- •Mild irritation or redness (uncommon)
- •Contact allergy possible, as with any skincare ingredient
Frequently Asked Questions
What is the recommended dose for Pentapeptide-18?
About 2-5% of the commercial solution in a finished product
How do you administer Pentapeptide-18?
Topical (serums, creams)
When is the best time to take Pentapeptide-18?
Morning and/or evening, on clean skin
How long should you use Pentapeptide-18?
28 days to 2 months in studies; ongoing use to maintain any effect
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.