How to Use Palmitoyl Tripeptide-38
Complete guide to Palmitoyl Tripeptide-38 dosing, administration, timing, and protocol recommendations.
Quick Overview
Palmitoyl tripeptide-38 is the active in Sederma's Matrixyl synthe'6, a newer member of the Matrixyl family launched around 2011. It is a three-amino-acid fragment with a fatty acid tail, sold as a wrinkle 'filler from the inside' for forehead lines and crow's feet. It is a cosmetic ingredient, not a drug, and the honest picture is simple: the efficacy claims come almost entirely from the company that makes it.
Dosing Guidelines
Common Dose
2% of the commercial ingredient in a finished product
Frequency
Once or twice daily
Dose Range
Commonly around 2% of the ingredient; the pure peptide content is far lower
Note: These are cosmetic formulation levels, not personal doses. The percentage refers to the supplier's ingredient solution, not pure peptide. There is no injectable or oral use with any human data behind it.
Administration Method
Topical (serums, creams)
Best Time to Take
Morning and/or evening, on clean skin before moisturizer
It is a leave-on cosmetic, so timing matters far less than consistent daily use. Pair daytime use with sunscreen, which does more for wrinkles than any peptide.
Protocol Duration
About 2 months in the manufacturer's study before changes were measured; ongoing use to keep any effect
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Generally well tolerated in cosmetic use
- •Mild irritation, redness or stinging (uncommon, often from the overall formula)
- •Contact allergy possible, as with any skincare ingredient
Frequently Asked Questions
What is the recommended dose for Palmitoyl Tripeptide-38?
2% of the commercial ingredient in a finished product
How do you administer Palmitoyl Tripeptide-38?
Topical (serums, creams)
When is the best time to take Palmitoyl Tripeptide-38?
Morning and/or evening, on clean skin before moisturizer
How long should you use Palmitoyl Tripeptide-38?
About 2 months in the manufacturer's study before changes were measured; ongoing use to keep any effect
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.