How to Use NAD+
Complete guide to NAD+ dosing, administration, timing, and protocol recommendations.
Quick Overview
NAD+ is not a peptide at all, it is a coenzyme every cell uses to move electrons around during energy production. It gets grouped with peptides because it is sold in the same places and injected the same way. Levels fall with age, which is the entire basis of the longevity interest, but the leap from that observation to injecting it is longer than most sellers admit.
Dosing Guidelines
Common Dose
50-100 mg subcutaneous, 2-3x weekly
Frequency
Two to three times weekly, or per clinic protocol for IV
Dose Range
50-750 mg depending on route
Note: Injected NAD+ and oral precursors are not interchangeable, and almost all the good human evidence belongs to the precursors, which are covered separately on our NAD+ Precursors profile. Where IV is used, the flushing and chest tightness people report is largely a function of infusion rate.
Administration Method
Subcutaneous injection or slow IV infusion. Fast infusion is the main cause of the flushing and chest tightness people report.
Best Time to Take
Morning
NAD+ is tied to energy metabolism and circadian signalling, and evening dosing is commonly reported to disturb sleep.
Protocol Duration
Ongoing use is common. No controlled long-term injectable data exists.
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Flushing, nausea and chest tightness during IV infusion, worse when infused quickly
- •Injection site irritation
- •Headache
- •Fatigue after infusion in some people
- •Long-term safety of repeated high-dose injection is not established
Frequently Asked Questions
What is the recommended dose for NAD+?
50-100 mg subcutaneous, 2-3x weekly
How do you administer NAD+?
Subcutaneous injection or slow IV infusion. Fast infusion is the main cause of the flushing and chest tightness people report.
When is the best time to take NAD+?
Morning
How long should you use NAD+?
Ongoing use is common. No controlled long-term injectable data exists.
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.