How to Use Melanotan I
Complete guide to Melanotan I dosing, administration, timing, and protocol recommendations.
Quick Overview
Melanotan I is the research name for afamelanotide, a 13-amino-acid synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH), also written as [Nle4, D-Phe7]-alpha-MSH or NDP-MSH. It is the only melanocortin peptide with regulatory approval: sold as Scenesse, it was approved by the EMA in 2014 and the FDA in 2019 to increase pain-free light exposure in adults with erythropoietic protoporphyria (EPP). It is given as a 16 mg bioresorbable implant under the skin by a clinician, not as a tanning shortcut.
Dosing Guidelines
Common Dose
500-1000 mcg daily (loading), then 500-1000 mcg 1-2x weekly (maintenance)
Frequency
Daily during loading (1-2 weeks), then 1-2x weekly maintenance
Dose Range
250-1000 mcg per injection
Note: Injected subcutaneously like MT-II. More selective than MT-II with fewer sexual side effects. Slower onset of tanning than MT-II. FDA version (Scenesse) is an implant for EPP patients only.
Administration Method
Subcutaneous implant (not injection)
Best Time to Take
Evening or before sun exposure
Similar to MT-II, evening use minimizes visible flushing. Pre-sun exposure maximizes tanning effect.
Protocol Duration
Long-term / as needed before sun season
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Nausea (common)
- •Skin darkening (intended effect)
- •Headache
- •Fatigue
- •Injection site reactions
Frequently Asked Questions
What is the recommended dose for Melanotan I?
500-1000 mcg daily (loading), then 500-1000 mcg 1-2x weekly (maintenance)
How do you administer Melanotan I?
Subcutaneous implant (not injection)
When is the best time to take Melanotan I?
Evening or before sun exposure
How long should you use Melanotan I?
Long-term / as needed before sun season
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.