How to Use Davunetide
Complete guide to Davunetide dosing, administration, timing, and protocol recommendations.
Quick Overview
Davunetide (NAP) is an eight-amino-acid fragment (NAPVSIPQ) of activity-dependent neuroprotective protein (ADNP), discovered at Tel Aviv University and given as a nasal spray. It was meant to protect brain cells by stabilizing microtubules, the scaffolding that tau normally supports. Its big test, a phase 2/3 trial in progressive supranuclear palsy (PSP), failed cleanly in 2012, and development stalled. It has since been revived by its inventors, who argue it works in women and are pursuing ADNP syndrome, but those claims rest on reanalyses of old data, not a new successful trial.
Dosing Guidelines
Common Dose
30 mg intranasal twice daily (PSP trial dose)
Frequency
Once or twice daily
Dose Range
5-30 mg per intranasal dose in trials
Note: These are trial doses from studies that mostly failed their main goals. They are not recommendations. No product is approved, and research-chemical NAP has no quality controls behind it.
Administration Method
Intranasal spray (an IV form, AL-208, was tested in cardiac surgery)
Best Time to Take
Twice daily (trial schedule)
The PSP trial used twice-daily nasal dosing. A 2025 review from the inventor's group discusses circadian effects, but no optimal time of day has been established in humans.
Protocol Duration
12 weeks to 52 weeks in trials
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Nosebleeds (12% vs 8% on placebo in the PSP trial)
- •Runny nose (10% vs 5%)
- •Nasal discomfort (10% vs under 1%)
- •Headache
- •Serious adverse events and deaths in the PSP trial were similar to placebo
Frequently Asked Questions
What is the recommended dose for Davunetide?
30 mg intranasal twice daily (PSP trial dose)
How do you administer Davunetide?
Intranasal spray (an IV form, AL-208, was tested in cardiac surgery)
When is the best time to take Davunetide?
Twice daily (trial schedule)
How long should you use Davunetide?
12 weeks to 52 weeks in trials
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.