How to Use ACTH 1-39
Complete guide to ACTH 1-39 dosing, administration, timing, and protocol recommendations.
Quick Overview
ACTH 1-39 is the full-length, 39-amino-acid adrenocorticotropic hormone your pituitary gland makes to tell the adrenal glands to produce cortisol. As a drug it has been around since the 1950s: the FDA first approved H.P. Acthar Gel in 1952, and it is still prescribed for infantile spasms, multiple sclerosis flares, and a long list of inflammatory conditions. It is one of the few compounds in this database with a real approval behind it, but the honest caveat is that for most of its labeled uses the modern evidence that it beats ordinary, far older corticosteroids is thin.
Dosing Guidelines
Common Dose
40-80 units every 24-72 hours (labeled adult dose)
Frequency
Daily to every 3 days, depending on indication
Dose Range
40-120 units per dose in adults; 150 U/m2 per day in infantile spasms
Note: These are the labeled prescription doses for the approved gel products, which are dosed in USP units, not micrograms. Dose and frequency are individualized by the prescriber, and courses after prolonged use are tapered to avoid adrenal insufficiency. There are no validated doses for unapproved synthetic ACTH 1-39.
Administration Method
Intramuscular or subcutaneous injection of a gelatin depot (intramuscular only for infantile spasms; never intravenous)
Best Time to Take
As prescribed (labeled taper doses are given in the morning)
ACTH drives cortisol release, which naturally peaks in the morning. The label's infantile spasms taper schedule uses morning doses, and timing otherwise follows the prescriber's regimen.
Protocol Duration
Short courses (typically 2-3 weeks for MS flares), followed by a taper after prolonged use to avoid adrenal insufficiency
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Infections (the most common serious risk, especially in infants)
- •High blood pressure
- •Fluid retention and weight gain
- •Increased appetite
- •Elevated blood sugar and glucose intolerance
Frequently Asked Questions
What is the recommended dose for ACTH 1-39?
40-80 units every 24-72 hours (labeled adult dose)
How do you administer ACTH 1-39?
Intramuscular or subcutaneous injection of a gelatin depot (intramuscular only for infantile spasms; never intravenous)
When is the best time to take ACTH 1-39?
As prescribed (labeled taper doses are given in the morning)
How long should you use ACTH 1-39?
Short courses (typically 2-3 weeks for MS flares), followed by a taper after prolonged use to avoid adrenal insufficiency
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.