How to Use Acetyl Tetrapeptide-5
Complete guide to Acetyl Tetrapeptide-5 dosing, administration, timing, and protocol recommendations.
Quick Overview
Acetyl tetrapeptide-5 is a short synthetic peptide sold by Lipotec (now Lubrizol) as Eyeseryl, made for eye creams that target under-eye puffiness. The pitch is that it reduces fluid leaking into the tissue under the eyes. It is a cosmetic ingredient, and nearly all of the human data comes from the company that sells it.
Dosing Guidelines
Common Dose
1% of the Eyeseryl solution in an eye cream
Frequency
Twice daily
Dose Range
1-10% of the commercial solution; actual peptide content is a tiny fraction of that
Note: These are cosmetic formulation levels, not personal doses. Results, if any, were measured after about a month. It targets fluid puffiness and will not change fat-pad eye bags or loose skin.
Administration Method
Topical (eye creams, gels, serums)
Best Time to Take
Morning and evening, gently patted under the eyes
Fluid puffiness tends to be worst in the morning, so morning use makes sense, and the manufacturer studies used twice-daily application.
Protocol Duration
28-60 days in manufacturer studies; ongoing use to maintain any effect
Possible Side Effects
Not everyone experiences these. Individual responses vary.
- •Generally well tolerated
- •Mild stinging or redness around the eyes (uncommon, often from the overall formula)
- •Eye irritation if product gets into the eye
- •Contact allergy possible, as with any skincare ingredient
Frequently Asked Questions
What is the recommended dose for Acetyl Tetrapeptide-5?
1% of the Eyeseryl solution in an eye cream
How do you administer Acetyl Tetrapeptide-5?
Topical (eye creams, gels, serums)
When is the best time to take Acetyl Tetrapeptide-5?
Morning and evening, gently patted under the eyes
How long should you use Acetyl Tetrapeptide-5?
28-60 days in manufacturer studies; ongoing use to maintain any effect
This information is for educational purposes only. Always consult with a healthcare professional before using any peptide. Dosing information is based on research literature and community reports, not medical advice.