Melanotan II vs Melanotan I
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: MT-II, MT2
A synthetic analog of alpha-melanocyte stimulating hormone (α-MSH). Known for inducing skin tanning and having effects on libido and sexual function.
Also: Afamelanotide, Scenesse
A 13-amino acid synthetic analog of α-MSH that stimulates melanin production. FDA-approved (as Scenesse) for treating phototoxicity in patients with erythropoietic protoporphyria (EPP). More selective than Melanotan II with fewer side effects.
Key Comparison Insights
- Melanotan I is FDA approved, while Melanotan II remains in research stages.
- Melanotan II is categorized as Sexual Health, while Melanotan I is Skin & Hair.
- Melanotan I has stronger research evidence (FDA Approved) compared to Melanotan II (Limited Research).
Detailed Comparison
| Attribute | Melanotan II | Melanotan I |
|---|---|---|
| Category | Sexual Health | Skin & Hair |
| FDA Status | Not FDA Approved | FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | MT-II binds to melanocortin receptors (MC1R for tanning, MC4R for sexual effects). MC1R activation stimulates melanin production in skin cells. MC4R activation in the brain influences sexual arousal and erectile function. | Melanotan I binds to melanocortin 1 receptors (MC1R) on melanocytes, stimulating eumelanin production. This increases skin pigmentation and provides photoprotection. Unlike MT-II, it has minimal affinity for MC3R and MC4R, resulting in fewer sexual and appetite-related side effects. |
| Common Dosing | 250-500 mcg daily (loading), then 500-1,000 mcg weekly (maintenance) Daily during loading (1-2 weeks), then weekly maintenance | 500-1000 mcg daily (loading), then 500-1000 mcg 1-2x weekly (maintenance) Daily during loading (1-2 weeks), then 1-2x weekly maintenance |
| Administration | Subcutaneous injection | Subcutaneous implant (not injection) |
| Typical Duration | Loading phase 2-3 weeks, then maintenance | Long-term / as needed before sun season |
| Best Time to Take | Evening or before sun exposure | Evening or before sun exposure |
Possible Side Effects May vary by individual |
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| Research Summary | Research demonstrates effective skin darkening without UV exposure, though UV enhances effects. Studies show improvement in erectile dysfunction. Originally developed for skin cancer prevention. PT-141 (bremelanotide) was derived from this research. | FDA approved in 2019 for EPP after successful Phase III trials showing significant increase in pain-free time in sunlight. Also studied for vitiligo, polymorphous light eruption, and solar urticaria. Clinuvel Pharmaceuticals developed and markets it as Scenesse. |
Frequently Asked Questions: Melanotan II vs Melanotan I
What is the difference between Melanotan II and Melanotan I?
Melanotan II is a sexual health peptide that a synthetic analog of alpha-melanocyte stimulating hormone (α-msh). known for inducing skin tanning and having effects on libido and sexual function. Melanotan I is a skin & hair peptide that a 13-amino acid synthetic analog of α-msh that stimulates melanin production. fda-approved (as scenesse) for treating phototoxicity in patients with erythropoietic protoporphyria (epp). more selective than melanotan ii with fewer side effects. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Melanotan II or Melanotan I?
Neither is universally "better" - the choice depends on your specific goals. Melanotan II is typically used for sexual health purposes, while Melanotan I is used for skin & hair. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Melanotan II and Melanotan I be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Melanotan II and Melanotan I together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of Melanotan II and Melanotan I is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.