Semaglutide vs Dulaglutide
Comprehensive side-by-side comparison of mechanisms, dosing, side effects, and research
Also: Ozempic, Wegovy
A GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management. One of the most effective pharmaceutical weight loss interventions available.
Also: Trulicity
An FDA-approved weekly GLP-1 receptor agonist for type 2 diabetes. Fused to an Fc antibody fragment for extended duration of action.
Key Comparison Insights
- Both Semaglutide and Dulaglutide are FDA approved medications.
- Both peptides belong to the Weight Loss category, suggesting similar primary applications.
Detailed Comparison
| Attribute | Semaglutide | Dulaglutide |
|---|---|---|
| Category | Weight Loss | Weight Loss |
| FDA Status | FDA Approved | FDA Approved |
| Clinical Status | Pre I II III IV FDA | Pre I II III IV FDA |
| Mechanism of Action | Semaglutide mimics the GLP-1 hormone, slowing gastric emptying, increasing insulin secretion, reducing glucagon release, and acting on brain appetite centers to reduce hunger and increase satiety. It has 94% amino acid similarity to human GLP-1. | Dulaglutide consists of two GLP-1 analogs linked to a modified human IgG4 Fc fragment. This structure extends half-life to about 5 days, allowing weekly dosing. Works through standard GLP-1 receptor activation. |
| Common Dosing | 1-2.4 mg weekly (after titration) Once weekly | 1.5-4.5 mg weekly Once weekly |
| Administration | Subcutaneous injection weekly, or oral (Rybelsus) | Subcutaneous injection weekly |
| Typical Duration | Long-term / chronic use | Long-term / chronic use |
| Best Time to Take | Morning, same day each week | Before bed or morning (fasted) |
Possible Side Effects May vary by individual |
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| Research Summary | STEP trials demonstrated average weight loss of 15-17% body weight over 68 weeks. SELECT trial showed 20% reduction in major cardiovascular events. Proven efficacy for glycemic control in type 2 diabetes with A1C reductions of 1.5-2%. | AWARD program showed significant A1C reduction and weight loss. REWIND trial demonstrated cardiovascular benefits in broader diabetic population. Generally shows 3-5% weight loss in trials. |
Frequently Asked Questions: Semaglutide vs Dulaglutide
What is the difference between Semaglutide and Dulaglutide?
Semaglutide is a weight loss peptide that a glp-1 receptor agonist fda-approved for type 2 diabetes and chronic weight management. one of the most effective pharmaceutical weight loss interventions available. Dulaglutide is a weight loss peptide that an fda-approved weekly glp-1 receptor agonist for type 2 diabetes. fused to an fc antibody fragment for extended duration of action. The main differences lie in their mechanisms of action and clinical applications.
Which is better, Semaglutide or Dulaglutide?
Neither is universally "better" - the choice depends on your specific goals. Semaglutide is typically used for weight loss purposes, while Dulaglutide is used for weight loss. Always consult with a healthcare provider to determine which may be appropriate for your situation.
Can Semaglutide and Dulaglutide be used together?
Some peptide protocols combine multiple compounds for synergistic effects. However, using Semaglutide and Dulaglutide together should only be considered under medical supervision, as both compounds have their own side effect profiles and potential interactions. Research on their combined use may be limited.
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Educational Information Only
This comparison of Semaglutide and Dulaglutide is for educational purposes only. Neither this comparison nor any information on this site constitutes medical advice. Always consult with qualified healthcare providers before making decisions about peptides or other substances.