TB-500
A synthetic 17-amino acid fragment of Thymosin Beta-4 (TB-4). NOT the same as TB-4 - TB-500 has a longer half-life (~2-4 days vs ~2 hours) and is the active region responsible for tissue repair and cell migration. Note: Many vendors mislabel TB-4 as 'TB-500' in premixed products.
Mechanism of Action
TB-500 is derived from the active region of the full Thymosin Beta-4 protein. It promotes cell migration by binding to and sequestering actin, a protein essential for cell movement. It upregulates actin expression, promotes angiogenesis, reduces inflammation, and facilitates hair follicle stem cell migration for wound healing.
Research Summary
Research shows significant wound healing acceleration, cardiac tissue repair after heart attack in animal models, and anti-inflammatory effects. Studies demonstrate improved recovery from dermal wounds and muscle injuries. Human clinical trials ongoing for wound healing applications.
Research Protocols
Note: Doses observed in research studies
Common Doses
Duration
4-6 weeks loading, then maintenance
Administration
Subcutaneous or intramuscular injection
Timing & Administration
HealingAs a Healing peptide: Morning or evening is the recommended administration time.
Best Time to Take
Morning or evening
2-3 times per week
Food Recommendation
either
Why This Timing?
Based on mechanism of action: TB-500 has a long half-life, so timing is flexible. Consistency matters more than specific time of day.
Timing recommendations are based on pharmacological principles and mechanism of action, not dedicated clinical trials on administration timing. Most peptide studies focus on efficacy rather than optimal timing. Consult a healthcare provider for personalized guidance.
Side Effects & Considerations
- ●Generally well-tolerated
- ●Injection site reactions
- ●Headache
- ●Fatigue
- ●Nausea
- ●May trigger histamine release - use caution with MCAS or histamine sensitivity
- ●Theoretical concern for cancer cell motility
- ●Contraindicated with active cancer
- ●Limited long-term safety data
References
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Educational Information Only
This information is provided for educational purposes only and is not intended as medical advice. Always consult with qualified healthcare providers before making any decisions about peptides or other substances. The protocols listed reflect doses observed in research studies, not recommendations.